2 day course: 4th & 5th June 2018

The importance of exploratory clinical research prior to the launch of a large-scale definitive phase III clinical trial is becoming increasingly recognised, both in the pharmaceutical industry and in public sector medical research.  Dose-escalation studies are first-in-human studies intending to determine a safe dose or range of doses which can be taken forward for further development.  Advances in the identification of medical biomarkers of therapeutic effect and in statistical techniques based on adaptive designs and Bayesian inference now allow such studies to be designed efficiently, to take account of information from a variety of sources and to combine objectives such as establishing safety and seeking evidence of a potential benefit.

This course presents state of the art methodology for dose-escalation studies.  The course will be delivered through a mixture of lectures, practical sessions and discussion sessions.

Course fees

Course fees are only charged for participants external to Lancaster University.

Please click here for details about course fees.

External participants: once you have registered please click here to pay.

Accommodation details

Lancaster University offers affordable accommodation on campus, and there are a range of options in the city.
Please click here for further details.

Waiting list policy

If the course is fully booked please complete the registration form, as you will be placed on a waiting list. You will be allocated a place if more places become available or if people cancel.

We will make every attempt to accommodate Lancaster University staff and postgraduate research students on our courses. However, if a course becomes fully booked we reserve the right to give priority to students on the MSc in Statistics, MSc in Data Science, and external participants.

Cancellation policy

Registrations are transferable to another statistics short course or individual at any time. Full refunds will be given for cancellation 10 or more working days before the course start date. Otherwise the full course fee will be charged.

Programme:

Model-based dose-escalation in oncology
Dose-escalation in healthy-volunteer studies
Bayesian curve-free dose-escalation for drug combinations
Dose-escalation designs incorporating multiple endpoints.